This is a very common question in my practice. If you are using progesterone to stabilize your hormones and your sleep, it is best to take oral progesterone before bed. If you are using a topical progesterone cream or gel, it will still also be helpful to get a restful night of sleep. Remember, that topical progesterone is around ten times the potency of an oral form of progesterone. This means that 30 mg progesterone cream potency is ten times the potency of oral progesterone.
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Therefore, an equivalent oral dose would be 300mg. This is because 90% of the oral progesterone pill is metabolized by what is called “first pass” in the liver. The breakdown of the progesterone into various metabolites can aid in disrupted sleep patterns, insomnia, hot flashes and night sweats.
While the research on progesterone is still emerging, it is likely that study results will continue to reveal the health benefits of progesterone.